p53: Regular or super?

“Super p53” Mice Display Retinal Astroglial Changes

Tumour-suppressor genes, such as the p53 gene, produce proteins that inhibit cell division under adverse conditions, as in the case of DNA damage, radiation, hypoxia, or oxidative stress (OS). The p53 gene can arrest proliferation and trigger death by apoptosis subsequent to several factors. In astrocytes, p53 promotes cell-cycle arrest and is involved in oxidative stress-mediated astrocyte cel...

Enlarging the classes of super edge-magic 2-regular graphs

A graph G is called super edge-magic if there exists a bijective function f : V (G) ∪ E (G) → {1, 2, . . . , |V (G)|+ |E (G)|} such that f (V (G)) = {1, 2, . . . , |V (G)|} and f (u) + f (v) + f (uv) is a constant for each uv ∈ E (G). A graph G with isolated vertices is called pseudo super edge-magic if there exists a bijective function f : V (G) → {1, 2, . . . , |V (G)|} such that the set {f (...

Five regular or nearly-regular ternary quadratic forms

Shift-or string matching with super-alphabets

Given a text T [1 . . . n] and a pattern P [1 . . .m] over some alphabet Σ of size σ, we want to find all the (exact) occurrences of P in T . The well-known shift-or algorithm solves this problem in time O(ndm/we), where w is the number of bits in machine word, using bit-parallelism. We show how to extend the bit-parallelism in another direction, using super-alphabets. This gives a speed-up by ...

p53: Pro-aging or pro-longevity?

continues to surprise biologists. For nearly a decade, it was thought to be an oncogene [1, 2], only to be subsequently declared a potent tumor suppressor [3, 4]. Initially characterized as a transcriptional activator, we now know p53 is also a transcriptional repressor [5]. And just as it seemed p53 activities were confined to the nucleus, it became apparent that p53 also functioned in the cyt...